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LSD1 inhibitor 24
CAS No. 1853269-07-4
LSD1 inhibitor 24( —— )
Catalog No. M12865 CAS No. 1853269-07-4
LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameLSD1 inhibitor 24
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NoteResearch use only, not for human use.
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Brief DescriptionLSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM.
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DescriptionLSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM; demonstrates attenuating the hERG inhibition and improving oral bioavailability.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1853269-07-4
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Formula Weight505.982
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Molecular FormulaC26H25ClFN7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(N=C(N1C2=CC3=C(N(N=C3C=C2)C)Cl)C4=CC(=C(C=C4)C#N)F)C(=O)N5CCCC(C5)NC
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Chemical Name(R)-4-(1-(3-chloro-2-methyl-2H-indazol-5-yl)-5-methyl-4-(3-(methylamino)piperidine-1-carbonyl)-1H-imidazol-2-yl)-2-fluorobenzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nie Z, et al. Bioorg Med Chem Lett. 2018 Nov 3. pii: S0960-894X(18)30855-2.
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